Chunk #15 — 3. Results — 3.1. Evaluating the interaction between the 5-HTTLPR short allele and childhood maltreatment in predicting persistent adult depression

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Serotonin transporter gene moderates childhood maltreatment's effects on persistent but not single-episode depression: replications and implications for resolving inconsistent results.

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We began by evaluating genetic (5-HTTLPR) and environmental (childhood maltreatment) main effects. There was no consistent association between 5-HTTLPR and persistent depression in either cohort (Table 1). In contrast, childhood maltreatment was strongly associated with persistent depression in both cohorts (Table 2). Individuals who were maltreated in childhood were significantly more likely to experience persistent depression in adulthood, in Dunedin (RD of 8.2% per level of maltreatment, p=0.0002) and in E-Risk (RD of 15.7% per level of maltreatment, p<0.0001).