Gene-level overlaps recapitulated the previously reported genetic architecture of brain disorders25: psychiatric disorders exhibited strong overlaps in their ranked gene lists, whereas degenerative disorders did not display significant overlaps (Extended Data Fig. 7a). Among psychiatric disorders, neurodevelopmental disorders (ADHD and ASD) and adult-onset psychiatric disorders (BD, SCZ, and MDD) showed strong overlaps, indicating shared neurobiological bases. The correlation between RRHO and genetic correlation was 0.79 (Extended Data Fig. 7b, P-value=8.08x10–9), demonstrating that gene-level association statistics from H-MAGMA reflect shared genetic architecture, and hence can be further used to decipher the biological mechanisms underlying shared genetic architecture among psychiatric disorders.
