Cross-disorder GWAS of eight psychiatric disorders recently identified more than a hundred GWS loci increasing risk for multiple disorders, further providing evidence of widespread pleiotropy among psychiatric disorders14. Shared genetic etiology across psychiatric disorders may underlie concerted developmental expression trajectories and cellular expression profiles of psychiatric disorder-associated genes (Fig. 2–3). Therefore, we next examined genes shared in multiple psychiatric disorders (n≥4) to identify common molecular mechanisms of psychiatric disorders (see Methods for gene selection).
