the LCLs (Supplemental Table S1). Some genes show evidence from several of these analyses. For example, TSPAN5 (tetraspanin 5) is decreased in the hippocampus (McClintick et al., 2013) and frontal cortex (Liu et al., 2007) of alcoholics, increased in the dorsal raphe nucleus (McClintick et al., 2015) and central core of the amygdala (McBride et al., 2010) of P rats in binge-like models of drinking, and associated with alcohol consumption (Clarke, et al., 2017). AUTS2 (activator of transcription and developmental regulator) has been associated with alcohol drinking (Schumann et al., 2011) and was decreased in post-mortem frontal cortex of alcoholics (Liu et al., 2007). CHL1 (cell adhesion molecule L1 like) was associated with response to trauma and total AUDIT score (Almli et al., 2017) and decreased in post-mortem frontal cortex (Liu et al., 2007).
