We examined other datasets to look for converging evidence supporting a potential role for the genes affected by ethanol in either predisposition to or effects of ethanol. Studies of post mortem brains from AD vs. control individuals have identified 928 of these 4456 genes as differentially expressed in at least one brain region (Supplemental Table S1). Forty-eight genes show some evidence of association with alcohol dependence or consumption in the NHGRI catalog (at p ≤ 9×10−6; Table 4 and Supplemental table S1). Genes differentially expressed in the brains of P rats consuming large amounts of ethanol over the course of 4 to 10 weeks (Bell et al., 2009; McBride et al., 2014; McBride, Kimpel, McClintick, Ding, Hauser, et al., 2013; McBride et al., 2010; McClintick et al., 2015, 2016, 2018) matched 1214 of the genes affected by ethanol exposure in the LCLs (Supplemental Table S1). Some genes show evidence from several of these analyses. For example, TSPAN5 (tetraspanin 5) is decreased in the hippocampus (McClintick et al., 2013) and frontal cortex (Liu et al., 2007) of alcoholics, increased in the
