Among genes affected by ethanol treatment, STXBP1 (syntaxin binding protein 1), PEA15 (phosphoprotein enriched in astrocytes 15), NPDC1 (neural proliferation, differentiation and control 1), NRXN3 (neurexin 3), SYT11 (synaptotagmin 11), CBLN3 (cerebellin 3 precursor), SYNGR1 (synaptogyrin 1), synaptophilin, and SYNPO (synaptopodin) are highly expressed in brain (Table 2). Several of these produce proteins that are known to reside in the post-synaptic density (Bayes et al., 2011). Ethanol caused a large decrease in the expression of GRM8 (glutamate metabotropic receptor 8), SSTR3 (somatostatin receptor 3) and CHRNB1 (cholinergic receptor nicotinic beta 1 subunit). The SSTR2 (somatostatin receptor 2) and CHRNA5 (cholinergic receptor nicotinic alpha 5 subunit) are increased.
