Chunk #28 — Results — Biometric Model Fitting: Substance Use Disorder — Multivariate models

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Age at first use and later substance use disorder: Shared genetic and environmental pathways for nicotine, alcohol, and cannabis.

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Subsequent model-fitting was conducted separately by sex for the following reasons: (1) results of univariate model-fitting indicated the possibility of sex-specific effects for AUD and CUD, and (2) there was evidence for a lack of measurement invariance of the symptom counts across men and women (see Measurement invariance).