3q27.3. CRYGS codes for an eye lens protein that has been implicated in cataract formation but has not been previously linked to substance abuse or behavioral disinhibition. Only one of the gene assignments for the top 13 SNPs has any obvious connection with a behavioral phenotype. The marker rs1793257 maps to an intron in OPCML, an opioid binding protein. Genetic variation in OPCML has been associated with depression (Schol-Gelok et al., 2010), although it has been more strongly linked with cancer risk.
