In these SH-SY5Y cells, 12,599 genes were expressed significantly over background, 97% of which were also expressed in at least one human brain region. CIE led to the differential expression of 1,498 genes at FDR < 0.20 (Supplementary Table S1; all data have been deposited into GEO, accession number GSE139408); 744 (50%) were decreased in expression. Most of the changes were small, with 91% (1365) having an absolute fold change ≤ 1.2 (full list in Supplementary Table S1). The 133 genes with absolute fold change ≥ 1.2 are listed in Table 1. Among the differentially expressed genes were those related to neuron function or development, including AMPA glutamate receptor subunit (GRIA2), ephrin B2 (EFNB2) and two ephrin receptors (EPHA2, EPHB4), genes encoding proteins that degrade neurotransmitters (MAOB and COMT), and dopa decarboxylase which produces dopamine and serotonin. Norepinephrine transporter SLC6A2 and glycine transporter SLC6A9 were increased in expression, while GABA transporter SLC6A11 was decreased; all three remove their respective neurotransmitter from the synaptic cleft. Several voltage-gated potassium channel subunits were increased in expression as were three calcium channel subunits. Calcium
