and glycine transporter SLC6A9 were increased in expression, while GABA transporter SLC6A11 was decreased; all three remove their respective neurotransmitter from the synaptic cleft. Several voltage-gated potassium channel subunits were increased in expression as were three calcium channel subunits. Calcium subunit CACNA2D2 had decreased expression. Several genes that are important for signaling were found in multiple affected pathways; these include MAP/ERK kinases (MAPK1, MAPK12, MAP2K1, MAP2K12, MAP3K1, MAP3K3), GAB1 and IRS1 that activate ERK signaling by binding to GRB2, and adenylate cyclases (ADCY1, ADCY3, ADCY6 and ADCY9; all with increased expression). Genes involved in neural development, axon growth, synaptogenesis, etc. were affected by ethanol, including growth factor receptors FGFR1 and FGFR2, WNT5A, and four frizzled receptors, FZD2, FZD4, FZD5 and FZD7 (all increased).
