Chunk #49 — RESULTS — Hyperexcitability is reversed by chronic Li treatment of LR DG-like neurons but not of NR neurons, and Li treatment reduces cell capacitance in both LR and NR neurons
cells (26% decrease, P = 0.03) and the hypoexcitable cells (39%, P = 0.004) (Supplementary Figure 4g and h). No significant differences were observed between fast and slow potassium currents or the spike height when comparing the Li-treated neurons in the ‘hyper’ vs ‘hypo’ excitable neurons of the LR and NR groups (Supplementary Figure 4c–f). The amplitude of the fast AHP of the hyperexcitable neurons was reduced in both the LR and NR neurons (a decrease of 23%, P = 0.05 for LR ‘hyper’ neurons, and a decrease of 30%, P = 0.01 for ‘hyper’ NR neurons); no significant change was seen in the ‘hypo’ LR and NR neurons (Supplementary Figure 4k and l). Although there were no significant differences observed in spike width when comparing the Li-treated neurons in the ‘hyper’ vs ‘hypo’ excitable neurons of the LR and NR groups, keeping in mind that the overall effect of Li is broadening of the spike in the LR group, neurons with a broader spike had shifted to the ‘hypo’ group (Supplementary Figure 4m and n). The threshold was less depolarized in the ‘hyper’ neurons of the LR group (5 mV less depolarized, P = 0.025). In the NR group,
