Chunk #48 — RESULTS — Hyperexcitability is reversed by chronic Li treatment of LR DG-like neurons but not of NR neurons, and Li treatment reduces cell capacitance in both LR and NR neurons
Analysis revealed that sodium currents of hyperexcitable neurons opened at a lower potential in both LR and NR neurons. The sodium currents that were measured at −40 mV, which have a large influence on cell excitability since they are close to the potential needed for evoking an action potential, changed with Li treatment. Increases of 257% P = 0.01 in LR neurons and 228% P = 0.07 in NR neurons were observed. The effect was in opposite directions in the ‘hypo’ neurons between LR and NR neurons (a decrease of 60%, P = 0.08, in the LR neurons vs an increase of 193%, P = 0.26, in NR neurons) (Supplementary Figure 4a and b). Cell capacitance decreased in the hypoexcitable LR neurons (29% decrease, P = 0.0015), whereas in the NR neurons the cell capacitance decreased in both the hyperexcitable cells (26% decrease, P = 0.03) and the hypoexcitable cells (39%, P = 0.004) (Supplementary Figure 4g and h). No significant differences were observed between fast and slow potassium currents or the spike height when comparing the Li-treated neurons in
