Chunk #47 — RESULTS — Hyperexcitability is reversed by chronic Li treatment of LR DG-like neurons but not of NR neurons, and Li treatment reduces cell capacitance in both LR and NR neurons
It was also interesting to observe how Li affected the different populations of hyperexcitable vs hypoexcitable neurons for LR and NR groups. Before Li treatment, 59% of the neurons were hyperexcitable in the LR group; after treatment, only 35% were hyperexcitable. In the NR group, 50% of the neurons were hyperexcitable before treatment, whereas after treatment the change was not marked and 47% were hyperexcitable. Although it seems that Li had almost no effect on NR neurons, it is not clear if this was the case or if there was a switching of neurons from the hyperexcitable NR group to the hypoexcitable NR group and vice versa. It is clear that more neurons shifted from the hyperexcitable group to the hypoexcitable group for the LR neurons. Note that in the Li treatment analysis, neurons at 22–30 days of differentiation were recorded, and hence the larger number of ‘hyper’ neurons compared to the previous section, where neurons were recorded and analyzed throughout the entire differentiation period.
