status would be a particularly good “candidate environment” when testing our hypothesis that SNPs in regulatory regions would be enriched for G×E effects. Twin studies of G×E effects using inferred genotypes typically show a fan-shaped pattern of effects, whereby additive genetic factors have more influence in certain environments, and less in others. Detecting a latent G×E effects with inferred genotypes implies that the majority of measured genes are likely to be moderated in the same way, such that the effect of measured genotypic influences on a phenotype varies across levels of the environment.
