We examined two research questions related to the incorporation of functional genomic information to understand the genetic and G×E influences on alcohol use outcomes in a population-based sample of young adult Finnish twins (Kaprio, 2013, Kaprio et al., 2002): 1) Do polygenic scores informed by DHS annotation predict lifetime alcohol problems better than conventional polygenic scores that include a mixture of DHS and non-DHS SNPs? And 2) Are DHS variants overrepresented among SNPs with G×E effects for alcohol misuse in a model where romantic relationship status is the environmental moderator? As a set, these questions contribute to efforts to enhance polygenic signal and empirically prioritize variants likely to be involved in G×E effects.
