Chromatin interaction mapping using Hi-C data in small bowel and liver prioritized 199 genes of which 18 genes are overlapping with genes prioritized by positional and/or eQTL mappings and 149 genes are located outside of the genomic risk loci (Supplementary Data 11). That resulted in a total of 276 prioritized genes including 215 novel candidates which were not reported in the original study (Table 2 and Supplementary Fig. 3). Of the 23 loci which are mapped to at least one gene by positional and eQTL mappings, additional 23 loci are mapped to candidate genes by chromatin interaction mapping, in which several of the genes prioritized from those loci are involved in immune system and cytokine signaling pathways (Supplementary Fig. 4 and Supplemental Data 12). One of these 23 risk loci, the 17q12 locus is mapped to six chemokine ligands by Hi-C in liver: CCL1, CCL2, CCL7, CCL8, CCL11, and CCL13. Additionally, prioritized genes include 11 cytokines (IL4, IL5, IL10, IL19, IL23R, IL24, IL27, IL33, IL1RL1, IL18R1, and IL18RAP) wherein IL18R1 and IL18RAP are also mapped by eQTLs in whole blood
