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Chunk #14 — MATERIALS AND METHODS — Multiple test correction

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Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.
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We are examining 144 SNPs. A conservative Bonferroni correction would result in an uncorrected p-value threshold of α’ = 3.47 × 10−4 for an α of 0.05 for our primary experiment in AAs only. Even after accounting for correlation between SNPs (Li & Ji, 2005, Nyholt, 2004), the low correlations in AAs afford only a marginal reduction to 118 tests (α’=4.24 × 10−4).