The rs1344706 and rs12476147 SNPs were genotyped in the entire cohort to investigate their association with SZ and BD in the Costa Rica population. The genotyping success rate exceeded 98%, and the accuracy was >99%, according to random duplicated genotyping of 5% of samples. No significant deviation from Hardy–Weinberg equilibrium was observed either in cases, or in controls, or in both. The association analysis results of the genotyped SNPs are presented in Table 1. The minor A allele of the rs12476147 SNP, located in the exon 4 of the ZNF804A gene, showed association with an increased risk of SZ (p = 0.026, one tailed) using DFAM. In this analysis, we used a one-tailed test, since rs12476147 had been previously associated, so there was a prior direction of effect to assume. No significant association between rs1344706 and SZ or BD was observed using DFAM.
