General cognitive ability in the general population has shown to be substantially heritable with large consortium studies identifying multiple candidate associations indicating a polygenic inheritance (Davies et al., 2015). In a recent GWAS meta-analysis of 35,298 healthy individuals, rs76114856 in the CENPO gene and rs6669072 on chromosome 1 were found to be associated with cognitive performance (Trampush et al., 2017). In schizophrenia and psychotic illnesses, several candidate genes (ex: COMT, DTNBP1, NRG1, DISC1, ERBB4) implicating neurotransmitter pathways involving dopaminergic (Green et al., 2014) and glutamatergic signaling (Greenwood et al., 2011, Greenwood et al., 2013, Greenwood et al., 2016) have found to be associated with cognitive performance and/or cognitive deficits in patients, though such findings have not produced knowledge that is translatable to clinical practice (Ehrenreich and Nave, 2014).
