In the adult case control sample, alcohol dependence was analyzed using logistic regression to estimate odds ratios for the variant rs1229984. Maximum drinks consumed in a 24-hour period (MaxDrinks) was examined by linear regression of the log transformed number of drinks. Prior to log transformation, the few extreme values of maximum drinks in 24-hours (greater than 100) were set at 100. Each study was examined to determine which characteristics predicted alcohol dependence and maximum drinks consumed in a 24-hour period. Age, gender, nicotine dependence and cocaine dependence were significantly associated with alcohol dependence and maximum drinks consumed in a 24-hour period. Primary analyses were adjusted for sex, age (in quartiles), and nicotine and cocaine dependence.
