This study obtained informed consent from all participants and was conducted under generic approval from the National Health Service National Research Ethics Service (approval letter dated 17 June 2011, Ref 11/NW/0382) and under UK Biobank approval 4844 ‘Stratifying Resilience and Depression Longitudinally’ (principal investigator AMM). All components of GS have received ethical approval from the National Health Service Tayside Committee on Medical Research Ethics (REC Reference Number: 05/S1401/89) and written consent for the use of data was obtained from all participants.