Chunk #44 — Online Methods (Limit 3,000 words, at end of manuscript, currently 2,064) — Replication of gene expression prediction models in independent data
To estimate trans-ancestral prediction accuracy, GREX was calculated for 162 African-American individuals and 280 European individuals from the NIMH Human Brain Collection Core (HBCC) dataset (Supplementary Figure 2c). Predicted gene expression levels were compared to DLPFC expression levels measured using microarray. There was a significant correlation between the European and African-American samples for RCV2 values and RR2 values (rho = 0.66, 0.56; Supplementary Figure 3b,c). RR2 values were higher on average in Europeans, but were significantly correlated between African-Americans and Europeans (rho = 0.78, p < 2.2 × 10−16, Pearson test; Supplementary Figure 3d).
