We used the BrainXcan package (https://github.com/hakyimlab/brainxcan)103 to predict the association between the TUD phenotype and brain features. This approach uses genetically determined brain image-derived phenotypes (IDPs) to test brain region association with the TUD phenotype via linear regression. IDPs were constructed by training genetic predictors on original IDPs from MRI images via ridge regression.103 IDPs were retrieved from the BrainXcan database (https://zenodo.org/record/4895174). Only significant IDP associations with TUD that survived a Bonferroni correction are reported (93 IDPs tested; p<1.92E-04).
