In summary, commonly occurring beliefs that may be associated with genetic research participation among Blacks include mistrust, stigma, perceived benefits or harm, and perceived causes of psychiatric illness. Although these themes have been identified, few, if any, studies have directly linked them to willingness to participate in psychiatric genetic research. Using an educationally and ethnically diverse sample of Blacks, Hispanics, and Whites, the purpose of this study is to first determine differences among the groups in willingness to participate in genetic studies of psychiatric disorders, and how these differences relate to attitudes, beliefs, age, and education.