Compliance is a crucial issue in pharmacotherapy in general, but with disulfiram in particular it has been emphasized by many authors [2], [17], [18], [23]. The highest success rates have been with patients who have chosen this type of treatment and are thus highly compliant or are receiving disulfiram under supervision [46]. Some authors have gone so far as to state that unsupervised administration is of limited utility [17], [47], [48].
