The genotype distributions for the two SNPs that were selected were not significantly different from the theoretical Hardy-Weinberg equilibrium values in independent tests of the 48 healthy subjects used in the resequencing procedure or 129 patient subjects used in the association analyses (data not shown). The clinical data of the 129 subjects who were included in the association study are provided in Table 5. Rescue analgesics were required in 59 patients. Doses of rescue analgesics administered to patients are shown in Table 5. More detailed clinical data stratified by each genotype (KCNJ6 G-1250A and A1032G) are presented as Supporting Information in Table S1.
