We conducted a replication analysis of the 162 lead SNPs identified at genome-wide significance in Okbay et al.’s10 pooled (discovery and replication) meta-analysis (N = 405,073). Of the 162 SNPs, 158 pass quality-control filters in our updated meta-analysis. To examine their out-of-sample replicability, we calculated Z-statistics from the subsample of our data (N = 726,808) that was not included in Okbay et al. Let the Z-statistics of association from, respectively, Okbay et al., the new data, and our final EA3 meta-analysis, be denoted by Z1, Z2 and Z. Since our meta-analysis used sample-size weighting35, Z2 is implicitly defined by: Z=N1NZ1+N2NZ2, where SNP subscripts have been dropped and N’s are sample sizes. Because this formula holds when Z1 and Z2 are independent, the implicitly-defined Z2 is interpreted as the additional information contained in the new data.
