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Chunk #15 — Results — Identification of eQTLs

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Identification of single nucleotide polymorphisms regulating peripheral blood mRNA expression with genome-wide significance: an eQTL study in the Japanese population.
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The procedure used for SNP-probe pair selection (Figure 1) generated 1,554 pairs, which are listed in Table S1. These SNP-probe pairs consisted of 1,153 SNPs, defined as eQTL SNPs, and 185 probes. For 122 of these 185 probes, we could identify the corresponding gene from the HapMap database (Release 28). Since several of the probes targeted the same gene, the total number of genes identified was 107. As shown in Figure 2, the majority of the eQTL SNPs were located in intronic (45% and 48% for cis- and trans-eQTL SNPs, respectively) or intergenic (33% and 40% for cis- and trans-eQTL SNPs, respectively) regions.