The top 10 associations between SNP genotypes and time to AIDS-diagnosis, had P-values smaller than 5.25×10−5, with P = 3.50×10−6 for the strongest statistical association (SNP rs1523635; Table 1). The top 10 associations between SNP genotypes and time to AIDS-related death had P-values smaller than 4.43×10−5, with P = 8.32×10−6 for the strongest statistical association (SNP rs7374396; Table 2). None of the associations between SNP genotypes and time to AIDS or AIDS-related death were genome-wide significant. However, the minor alleles of SNPs that ranked in the top 10 for association with time to AIDS or AIDS-related death were also associated with survival to other endpoints (Tables 1 and 2). None of the SNP genotypes identified to be associated with AIDS-diagnosis were associated with survival time after AIDS-diagnosis, indicating that their potential effect is at an earlier stage in the course of infection (Table 1).
