Using sLORETA in a Go/No-Go task, Pandey and colleagues (2012b) reported significantly smaller N2-related activations during the No-Go condition at bilateral anterior prefrontal regions in alcoholics compared with control subjects (see figure 2). Further, sLORETA analysis in a MGT task revealed that alcoholics, as compared with control subjects, showed significantly lower P3-related current density activations at cingulate gyrus, along with significantly reduced N2-related current density at postcentral gyrus, inferior frontal gyrus, and precentral gyrus during both loss and gain conditions (Kamarajan et al. 2010) (see figure 2). These studies demonstrate the utility of LORETA methods in revealing the activity patterns of key brain regions that are associated with neurocognitive dysfunction in alcoholics and HR offspring.
