A recent GWAS was conducted using the full 10-item AUDIT in 20,328 EA research participants from 23andMe (7). Although this was the largest study to date using the AUDIT as a phenotype for GWAS, it was restricted to a single AUDIT measure and included no AAs. The lack of genome-wide significant results in this study may have resulted from the generally low AUDIT scores in the relatively high socioeconomic status sample, the use of a single measure rather than a longitudinal phenotype, and lack of data for the key variant, ADH1B*rs1229984, which was filtered out of that sample due to problems with genotyping and imputation (Abraham A. Palmer, personal communication, November 29, 2017).
