In the present analysis, we synthesize data from 88 studies to perform a multi-ancestry meta-analysis of GWAS data from European ancestry (EA) (n = 137,136 cases and 1,085,746 controls), African ancestry (AA) (n = 11,560 cases and 39,474 controls), and Native American ancestry (LAT) (n = 2,064 cases and 4,953 controls) samples, including analyses of the X chromosome. We follow-up on GWAS findings to examine global and local heritability, infer involvement of brain regions and neuronal systems using transcriptomic data, describe shared genetic effects with comorbid conditions, and use multi-omic data to prioritize a set of 43 putatively causal genes (Fig. 1). Lastly, we use this information to identify potential candidate pathways for future PTSD treatment studies. Together, these findings mark significant progress towards discovering the pathophysiology of trauma and stress-related disorders and inform future intervention approaches for PTSD and related conditions.
