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Chunk #26 — Discussion

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PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes.
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In HS we observed association of potential eQTL rs3765598 with SLE. This SNP is in a potential enhancer of regulatory chromatin site for CD4+CD25−CD45RO+ memory primary cells. Although the minor allele for rs3765598 is less common in Yorubans (MAF = 4%), and is more common in individuals of European descent (CEU MAF = 23%), it was not associated in our EA population (P = 0.75).