Neurophysiological literature on functional networks in FTLD is almost non-existent. One resting-state EEG study assessed functional connectivity in AD, FTLD, and persons with subjective memory complaints, and failed to find group differences.88 A subsequent MEG study of network organization in FTD patients however showed changes in the opposite direction to that observed in AD patients, toward an overly regular, ordered topology.78 This intriguing contrast aligns with resting-state fMRI results in AD and FTD58 to suggest that these disorders may exert divergent effects on large-scale networks (Figure 5),89 and that these effects may help distinguish these disorders during life.
