Last, we evaluated our sixth hypothesis specifying that CAD symptoms in early adolescence would contribute to increases in internalizing and/or externalizing symptoms in late adolescence. We also included unexamined cross-domain paths predicting internalizing symptoms at Wave 4 via externalizing. None of the additional paths were statistically significant. The addition of these paths contributed to deterioration in model fit on a range of fit indices, including model parsimony indices (Table 4), and resulted in a nonsignificant change in the chi-square value. Thus, an independent influence of early adolescent cannabis use problems on increasing late adolescent internalizing and externalizing symptoms was not supported.