However, the relative importance of genetic predisposition and of other etiological factors remains unclear. The symptoms of psychosis induced by MA are very similar to those of schizophrenia spectrum psychosis and include: lack of concentration, delusions of persecution, increased motor activity, disorganization of thoughts, lack of insight, anxiety, suspicion and auditory hallucinations [6]. 20%–38% of the subjects with MA induced psychotic disorders in the past had a change in diagnosis to either schizophrenia or affective psychosis on follow-up (Aggarwal et al. 2012; [24]). MA use was vulnerability to independent psychotic disorders. Positive psychotic symptoms of MA induced psychotic disorders can be resolved rapidly a few days after MA cessation and/or antipsychotic treatment. Glasner-Edwards et al. [17] reported that early treatment of psychotic symptoms in MA-dependent adults was associated with a better outcome at a 3-year follow-up. This highlights the importance of being aware of comorbidities in MA-dependent patients and the need for timely and integrated treatments for such disorders, regardless of whether they are substance-induced.
