MDs, HDs and M/HDs were particularly susceptible to mood disorders is noteworthy. In contrast, HDs were particularly more likely to have current substance-induced mood disorders than MDs and H/MDs. But no difference was found in lifetime rate of substance-induced mood disorders between HDs and H/MDs, which suggested that heroin use was highly relevant to mood alteration. Intense euphoria and well-being appear in heroin intoxication. Symptoms during withdrawal vary—someone feel anxious and agitated, while others experience temporary depression and anhedonia. Long-term use of opioids is associated with moderate to severe depression. Whereas MA intoxication is associated with euphoria, well-being, and perceived increased powers of thought, strength, and accomplishment [7, 42, 44]. In a follow-up study, current substance induced depression at baseline were found to be more prevalent in heroin dependent subjects than those who dependent on alcohol or cocaine [41]. The association between DSM-IV lifetime any mood disorders and opioid dependence (OR = 10.5) was found greater than the corresponding association for amphetamine dependence (OR = 6.9) in males [10]. Clinical recommendations for substance induced mood disorders may include watchful waiting
