Chunk #23 — RESULTS — Smokers at higher genetic risk were more likely to experience cessation failure

Source

Polygenic risk and the developmental progression to heavy, persistent smoking and nicotine dependence: evidence from a 4-decade longitudinal study.

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We next used the month-to-month life history calendars to look closely at cohort members’ smoking behavior during their 30s, when cessation was most common. Across 72 months of follow-up, n=277 cohort members smoked daily. 53% of these smokers made a quit attempt lasting one month or more. Relapse was common (occurring in 62% of quitters). Quitters at higher genetic risk were more likely to relapse and did so sooner after quitting (HR=1.22 [1.02-1.45]). Only 20% of daily smokers achieved successful cessation (abstinent for ≥1 year through age 38). Smokers at higher genetic risk were less likely to have achieved successful cessation at the end of follow-up (RR=0.73 [0.57-0.93]) (Figure 4 Panel C).