Assessment of cessation failure is challenging.50 Therefore, we looked for convergent evidence across two approaches to testing genetic associations with cessation failure. We first analyzed study members’ reports of cessation failure between ages 18-32 years. Across 14 years of follow-up, n=405 cohort members smoked daily. 90% of this group made at least one quit attempt and 51% reported a cessation failure at one or more assessments. Cohort members at higher genetic risk were more likely to experience cessation failure in their quit attempts (RR=1.11 [1.01-1.22]).
