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Chunk #5 — The Theoretical Basis for the Present Study

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Polygenic Score × Intervention Moderation: an Application of Discrete-Time Survival Analysis to Model the Timing of First Marijuana Use Among Urban Youth.
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adolescent tobacco and marijuana use (Musci et al., 2015b) based on the data drawn from the Ialongo et al. (1999) prevention intervention trial, Musci et al (2015c) tested whether the score would also moderate the impact of the intervention on survival to first cigarette smoked. Musci et al., (2015a) did in fact find a significant intervention × quit success score interaction. More specifically, the effect of the intervention on age of first cigarette smoked was greatest among those 1 SD above the mean on the polygenic score.