Chunk #42 — Results — Mecp2 isoform-specific expression correlates with DNA methylation at the Mecp2 regulatory elements

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Decitabine alters the expression of Mecp2 isoforms via dynamic DNA methylation at the Mecp2 regulatory elements in neural stem cells.

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In order to establish a link between Mecp2 isoform-specific expression and DNA methylation, we performed Pearson's correlation analysis by comparing normalized (log2) expression of Mecp2 in each dataset to the respective average percentage methylation levels over entire regions, as well as methylation at individual CpG sites (from both control and decitabine-treated cells).