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Chunk #25 — 4. DISCUSSION

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DSM-5 cannabis use disorder: a phenotypic and genomic perspective.
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Overall, rates of diagnostic DSM-5 cannabis use disorders appear to be modestly lower than those for DSM-IV abuse/dependence, but only in EA, particularly men. This finding is highly comparable with epidemiological analyses of alcohol symptomatology in U.S. (Agrawal et al., 2010; Martin et al., 2011a; Verges et al., 2011) and with results from the 2007 Australian National Survey of Mental Health and Wellbeing, which reported a decrease in the lifetime rate of cannabis use disorder from 6.2% to 5.4% when transitioning from DSM-IV to DSM-5 (Mewton et al., 2013). In our sample, this decrease was uniformly attributable to individuals who endorsed hazardous use alone, which results in a DSM-IV diagnosis of cannabis abuse but not a DSM-5 diagnosis of cannabis use disorder, because it falls below the latter's minimum two-symptom threshold. No differences were noted in AA men (or women), and this is also not surprising. Individuals endorsing this criterion alone tend to be of higher socio-economic standing (Keyes and Hasin, 2008) and tend to, overwhelmingly, endorse this criterion due to a history of drinking and driving (Agrawal et al.,