After Bonferroni correction, 179 traits or diseases were genetically correlated with AUDIT-C (Fig. 2c, upper panel; Supplementary Data 34). AUDIT-C was positively genetically correlated with lipids (e.g., HDL cholesterol concentration: rg = 0.361, p = 3.39 × 10−8), reproductive traits (e.g., age at menarche: 0.190, p = 4.20 × 10−8), and years of education (rg = 0.248, p = 1.40 × 10−16) and negatively correlated with anthropometric (e.g., BMI: rg = −0.350, p = 3.25 × 10−19), cardiometabolic (e.g., coronary artery disease: rg = −0.212, p = 8.28 × 10−8), glycemic (e.g., Type 2 diabetes: rg = −0.273, p = 2.34 × 10−7), lipid (e.g., triglyceride concentration: rg = −0.325, p = 1.29 × 10−10), and psychiatric (e.g., major depressive disorder (MDD) (rg = −0.216, p = 7.72 × 10−8) traits. After correction, 111 traits or diseases were genetically associated with AUD (Fig. 2c bottom panel; Supplementary Data 35), including positive genetic correlations with sleep disturbance (e.g., insomnia: rg = 0.280, p = 7.43 × 10−6), ever having smoked (rg = 0.581, p = 9.19 × 10−20), and multiple psychiatric
