Chunk #25 — Results — Genetic correlations

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Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.

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with AUD (Fig. 2c bottom panel; Supplementary Data 35), including positive genetic correlations with sleep disturbance (e.g., insomnia: rg = 0.280, p = 7.43 × 10−6), ever having smoked (rg = 0.581, p = 9.19 × 10−20), and multiple psychiatric disorders (e.g., alcohol dependence: rg = 0.965, p = 1.21 × 10−10; MDD: rg = 0.406, p = 2.19 × 10−20), and negative genetic correlations with aging-related factors (e.g., mother’s age at death: rg = −0.390, p = 8.09 × 10−8), intelligence (rg = −0.226, p = 6.79 × 10−8), years of education (rg = −0.263, p = 2.88 × 10−15), and quitting smoking (rg = −0.517, p = 1.12 × 10−5).