We tested the difference between genetic correlations for AUDIT-C and AUD using a two-tailed z-test. After correction for 714 tested traits, the genetic correlations for 188 traits showed significant differences between the two alcohol-related traits (Supplementary Data 36). We explored trait and disease associations for AUDIT-C-adjusted for AUD and AUD-adjusted for AUDIT-C, and found that the genetic correlations between the alcohol-related traits and other phenotypes did not differ substantially from the unadjusted ones (Supplementary Data 37, 38). Additionally, we explored genetic correlations for AUDIT-C-adjusted for BMI (Supplementary Data 39) and AUD-adjusted for BMI (Supplementary Data 40). Most of the genetic correlations for AUDIT-C-adjusted for BMI did not differ substantially from the unadjusted ones, except for anthropometric traits, where the negative correlation was attenuated (although still significant). Significant genetic correlations for AUD-adjusted for BMI did not differ substantially from those for AUD alone. We also explored prior GWAS associations for the GWS SNPs from AUDIT-C and AUD analyses and found associations with other phenotypes for five of them (Supplementary Data 41).
