Similar to other addictions, cannabis dependence is a complex disorder; thus, genetic interactions with factors such as behavioral traits and environmental conditions could contribute to addiction vulnerability. A growing number of family, twin and adoption studies have shown that cannabis-use disorder is influenced by heritability (30–80%) [7]–[15]. However, specific genetic determinants and behavioral factors remain unknown. In this study, we sought to examine factors relevant to cannabis-dependence risk by evaluating genetic polymorphisms of neural systems implicated in the actions of cannabis and to behavioral traits associated with addiction vulnerability.
