The TMEM18 gene located at chromosome 2p25, has recently been identified as a modulator of glioma-directed stem cell migration and may be involved in cell movement in general.43 The encoded protein is localized to the nucleus, widely expressed in fetal and adult tissues and well conserved among divergent species. TMEM18 contains one associated SNP from our study, rs2867125. The reported effect size in Europeans for rs2867125 is 0.061 s.d. unit of BMI,17 which is comparable to the effect size of 0.06 s.d. unit of BMI observed in our study, with same direction of the association.
