Sex-specific GWASs of alcohol consumption were also performed (Supplementary Figures 12 and 13). Only one novel locus (rs140089781) was identified in males on chromosome 2 in catenin-α2 (CTNNA2). rs140089781 was not analysed in females because of the low MAF of this SNP (MAF <0.001). All other loci identified in males or females had previously been identified at the level of genome-wide significance in the total sample (Supplementary Table 3).