In summary, we undertook a GWAS analysis of multiple indicators of behavioral disinhibition using more than 500K SNPs in a sample of over 7000 individuals of European ancestry. While we failed to find any confirmed associations that satisfy the recognized standard for declaring genomewide significance, consistent association findings were observed for several SNPs across the multiple indicators. These markers may be worthy of future investigation. A comparison of biometric and GCTA estimates of heritability for the five clinical phenotypes further suggests that the genetic architecture of the five clinical phenotypes is complex and that much of the heritable effects may not be accounted for by common SNPs.
