Chunk #37 — Results — Prolonged exposure to nondependent and alcohol dependent environment differentially alters proliferation, immature neurons and granule cell neurons in the hippocampal SGZ

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Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence.

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alcohol. On the other hand, prolonged dependence showed a greater decrease in total DCX-IR cells compared to nondependent drinking (F2,33 = 27.02, p < 0.01, Fig. 5b), the decrease in total number of DCX-IR cells was due to decreases in late phase cells (F2,33 = 27.02, p < 0.01, Fig. 5b), which indicates that prolonged exposure to alcohol vapors further attenuated the immature neuron population. Prolonged environment of nondependent drinking and alcohol dependence decreased hippocampal granule cell neurons (F2,14 = 4.9, p = 0.02, Fig. 5c).